With high population growth, large proportions of rural populations, and high levels of malnutrition, including micronutrient deficiencies, Mali and the Sahel region in general rank among the lowest on the United Nations Human Development Index. Seed Systems in Mali is a long-term project now led by Baloua Nebie following Eva Weltzien-Rattunde’s retirement from ICRISAT in 2016. It focuses on various aspects of participatory breeding for improving sorghum- and millet-based systems in the Sahel region. The project has from its inception in 2006 worked with a network of large farmer organizations in all three West Africa CoP countries. The research network orientation taken by this project was seen as a promising approach for building capacities for expanding farmers’ seed systems. A key aspect was to expand farmers’ capacities in terms of increasing the crop and varietal diversity in their systems. A network of variety testers, seed producers, and seed marketing specialists was built within these farmer organizations to enhance the reach of the seed.